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KMID : 0386520010100010489
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Research Institute of Korean Medicone
2001 Volume.10 No. 1 p.489 ~ p.494
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Effect of Samulanshintang (SA) on Stressed Rats
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Lim Seok-Rhin
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Abstract
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To determine the preventive effect of Samulanshintang (SA) on stress, we investigated the physiological change of rats which were applied immobilization stress. For immobilization stress, rats were placed in restrainer for 12 hours a day for 3 days. During application of stress, body weight of rats was measured. After sacrifice, 4 organs were taken for measurement of organ weight. Brain was homogenated and its catecholamine and serotonin contents were measured with HPLC. In our study, stress mainly induced increase of concentration of neurotransmitters in brain without other significant physical change of rats. SA inhibited stress induced changes of neurotransmitter content in brain.
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KEYWORD
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